Episodes

The episode begins with upcoming events, then examines the impact of Hurricane Milton and climate change on real estate and insurance. It explores the Nobel Prize in chemistry's tech implications, Google's antitrust issues, and big tech's future. The venture capital market is analyzed, focusing on fund returns. TikTok's role as a news source is debated amid national security concerns. Updates on the 2024 election and political strategies are provided, alongside insights into the startup ecosystem, social media, and the tech industry. Poker strategies are briefly discussed, followed by a sponsor segment from Wealthfront, and concludes with closing remarks.

Adyen Co-CEO Ingo Uytdehaage joins the conversation, discussing Adyen's competitive edge over Stripe. The episode delves into the challenges and strategies for building and scaling a tech company in Europe, with insights into Adyen's expansion into India. Ingo shares thoughts on stablecoins, financial deplatforming, and the role of AI in fintech, including the potential of open-source solutions. The discussion also covers the complexities of offering services in authoritarian countries, leveraging data for economic forecasting, and the dynamics of working as a Co-CEO.

In this episode, David Friedberg introduces a panel focused on the evolving eVTOL industry. The discussion features insights from Joby Aviation, Archer Aviation, and Wisk Aero, highlighting their unique approaches and innovations. Key consumer issues such as liquidity, scalability, and pro-eVTOL regions are examined. The panel delves into autonomous flight technology, redundancy, pilot necessity, and handling edge cases. Acoustic challenges, network creation through scale, marketing strategies, and battery technology are explored. The conversation wraps up with predictions on the commercial availability of eVTOLs and navigating FAA regulations.

David Friedberg engages in a conversation with Eli Lilly CEO Dave Ricks, exploring the global obesity epidemic and the discovery of GLP-1s. They discuss the effects of GLP-1s on various human functions and delve into the commercial aspects of drug discovery, including pricing strategies. The episode addresses criticism and research surrounding GLP-1 dependency, as well as the company's stock performance and political pressures tied to successful drugs. Dave Ricks shares insights on Eli Lilly's diverse drug portfolio beyond GLP-1s and the scientific advancements that excite him. The episode concludes with a discussion on scaling and influencing culture in a company with over a century of history.

The episode introduces Mark Cuban as the honorary fifth bestie, exploring his political activism, voting history, and advice to Donald Trump. Cuban offers a comprehensive assessment of Trump's presidency, discussing his response to BLM riots, foreign policy, and energy policies impacting inflation. The conversation evaluates the Biden-Harris administration's performance, including border policies and Kamala Harris' role. Cuban shares views on international conflicts and federal debt, recounts interactions with the SEC on crypto regulation, and discusses his sale of the Mavericks and focus on Cost Plus Drugs. The episode concludes with Cuban's future plans, his relationship with Elon Musk, and closing remarks.

This episode introduces Altos Labs and their quest to reverse aging, akin to a modern search for the fountain of youth. We delve into their groundbreaking research using Yamanaka factors to reverse aging in mice, exploring potential impacts on age reversal and disease treatment. The discussion covers organ rejuvenation and eliminating unhealthy cells, cellular reprogramming, and how exercise influences gene expression. We also explore market opportunities for cellular reprogramming technologies, concluding with insights into Altos Labs' organizational structure, funding, and the balance between research and product development.

In this episode, Jason Calacanis talks with Jake Loosararian from Gecko Robotics about robotics and infrastructure. Jake discusses Gecko's wall-climbing robots designed for asset maintenance and safety. They explore AI's role in robotics and manufacturing, Gecko's military collaborations, and strategies for emissions reduction and infrastructure renewal. The conversation covers customer engagement in the robotics market and overcoming challenges in infrastructure modernization. Jake also shares insights on balancing specialized and generalized robotics, the future with API platforms, and the investment landscape for deep tech, emphasizing infrastructure safety concerns.

In this episode, Jason opens with an emotional segment before diving into OpenAI's $150 billion valuation and ChatGPT-4 insights. Chamath discusses his appearance on the Joe Rogan Experience, leading to a conversation on AI's impact on knowledge work and OpenAI's shift from nonprofit to for-profit. The episode explores tech innovations like Apple's iOS 18, Meta's AR glasses, and ambient computing. They also discuss a blue-collar boom versus tech job decline and an education market correction. The conversation touches on geopolitical tensions, including the Middle East conflict and Ukraine war, wrapping up with light-hearted banter and closing remarks.