[ The Podcast ]
About.
The All-In Podcast delivers conversations worth having. Hosted by Chamath Palihapitiya, Jason Calacanis, David Sacks, and David Friedberg, the show features insider takes on business, technology, and society and interviews with the world's most influential thinkers.
[ Latest Episode ]
Martin Shkreli: Big Pharma's Blind Spot, Betting Against Quantum & What Prison Taught Him
Is quantum computing a one-trick business? Martin Shkreli explains why he’s short the sector despite losing millions, and why photonic computing may matter more. He and Jason unpack AI’s likely winners, drug discovery and pharma pricing, plus the ambition, ego and fear behind Shkreli’s decisions and what prison taught him about success and identity.
[ 10/10/2026 ]
Is AI becoming a tool, a moral framework or a new religion? The besties debate Anthropic’s view that Claude might be conscious, model welfare and alignment risks, plus OpenAI’s math breakthroughs and backlash. They also break down France’s riots, socialism, debt and bond-market pressure, then assess Grok Bot, OpenAI Dots, practical gains from AI and whether IP still matters.
[ 10/2/2026 ]
Can an AI safety framework work without new legislation? The besties unpack the White House accord pushing frontier model companies toward internal controls, external audits and board oversight. They debate superintelligence as an arms race, open-source AI, cyber defense, data centers and power, plus whether doomer narratives obscure strong growth, low unemployment and rising household income.
[ 9/30/2026 ]
Can fame become a durable business advantage? Jake Paul explains how attention, authenticity and hard work powered his move from social media into boxing, MVP and angel investing. Drew Taggart shares the Chainsmokers’ path from music to venture, while Jason and Chamath unpack Robinhood, follow-ons, liquidity and why the top 5% generate 90% of returns.